Publications
2025年
Weng Y, Wang Z, Sitosari H, Ono M, Okamura H, Oohashi T.Biofactors. [IF: 6.11], 2025 Jan-Feb;51(1):e2131. doi: 10.1002/biof.2131. Epub 2024 Oct 15.PMID: 39405562
Sitosari H, Fukuhara Y, Weng Y, Zheng Y, He Y, Zheng X, Ikegame M, Okamura H.J Cell Physiol. [IF: 6.38], 2025 Jan;240(1):e31524. doi: 10.1002/jcp.31524.
O-GlcNAcase transiently translocates to the cytoplasm and regulates osteoblast differentiation.
Zheng X, Tanai A, Sitosari H, Weng Y, Andini AD, Kimura K, Ikegame M, Okamura H, Xie X.J Oral Biosci. [IF: 0.96], 2025 May 22:100672. doi: 10.1016/j.job.2025.100672.
Aoki K, Yoshitani N, Kurio N, Yoshioka N, Teramachi J, Ikegame M, Okamura H*, Ibaragi S.
Angiogenin-induced osteoclastogenesis mediates bone destruction in oral squamous carcinoma.
Anticancer Research, 45(3), 1025-1033, 2025
doi: 10.21873/anticanceres.17489
Zheng Y, Wang Z, Weng Y, Sitosari H, He Y, Zhang X, Shiotsu N, Fukuhara Y, Ikegame M, Okamura H*
Gingipain regulates isoform switches of PD-L1 in macrophages infected with Porphyromonas gingivalis.
Scientific Reports, 15(1):10462, 2025
doi: 10.1038/s41598-025-94954-7
Zheng X, Weng Y, Satoh A, Tanai A, Ikegame M, Kimura K, Yoshitani N, Xie X, Okamura H*.PTPA localized in Golgi apparatus plays an important role in osteoblast differentiation.
Biochemical and Biophysical Research Communications, in press
doi: 10.1016/j.bbrc. 2025.151329
Tanai A, Fukuhara Y, Eguchi T, Kawai H, Ueda K, Ochiai K, Ikegame M, Okamoto K, Okamura H.
P. gingivalis-infected macrophage EVs cause adverse pregnancy outcomes.
Journal of Dental Research, in press
Books and chapters of books
岡村裕彦
胎盤と胎児の成長発育における歯周病由来の細胞外小胞の影響
細胞, 57(1), 82-85, 2025
2024年
Sitosari H, Fukuhara Y, Weng Y, Zheng Y, He Y, Zheng X, Ikegame M, Okamura H*.
High glucose inhibits O-GlcNAc transferase translocation in early osteoblast differentiation by altering protein phosphatase 2A activity.
Journal of Cellular Physiology, 240(1), e31524
doi: 10.1002/jcp.31524
Kato M, Tanai A, Fukuhara Y, Zheng X, Sitosari H, Yamamoto T, Ikegame M, Okamura H*.
b-catenin binds to Gsk-3b in liquid-liquid phase separation compartment in HEK293 cells
Journal of Hard Tissue Biology, 33(4), 213-218, 2024
Weng Y, Wang Z, Sitosari H, Ono M, Okamura H*, Oohashi T.
O-GlcNAcyalation regulates osteoblast differentiation through the morphological changes in mitochondria, cytoskeleton, and endoplasmic reticulum.
BioFactors, 51(1), e2131, 2024
doi:10.1002/biof.2131
Books and chapters of books
岡村裕彦
胎盤と胎児の成長発育における歯周病由来の細胞外小胞の影響
細胞, 56(10), 782-785, 2024
Books and chapters of books
岡村裕彦
胎盤と胎児の成長発育における歯周病由来の細胞外小胞の影響
細胞, 56(3), 188-191, 2024
2023年
Takemoto F, Uchida-Fukuhara Y, Kamioka H, Okamura H, Ikegame M.
Mechanical stretching determines the orientation of osteoblast migration and cell division.
Anatomical Science International, 98(4), 521-528, 2023
doi: 10.1007/s12565-023-00716-8
Yu Y, Uchida-Fukuhara Y, Weng Y, He Y, Ikegame M, Wang Z, Yoshida K, Okamura H, Qiu L.
Neuropilin 1 (NRP1) positively regulates adipogenic differentiation in C3H10T1/2 cells.
International Journal of Molecular Sciences, 24(8), 7394, 2023
doi: 10.3390/ijms24087394
Sitosari H, Morimoto I, Fukuhara Y, Weng Y, Zheng Y, Ikegame M, Okamura H.
Inhibition of protein phosphatase 2A by okadaic acid induces translocation of nucleocytoplasmic O-GlcNAc transferase.
Biochemical and Biophysical Research Communications, 646, 50-55, 2023
doi: 10.1016/j.bbrc.2023.01.033
2022年
Yuan H, Ikegame M, Fukuhara Y, Takemoto F, Yu Y, Teramachi J, Weng Y, Guo J, Yamada D, Takarada T, Li Y, Okamura H, Zhang B.Vestigil-like 3 plays an important role in osteoblast differentiation by regulating the expression of osteogenic transcription factors and BMP signaling.
Calcified Tissue Interanational, 111(3), 331-344, 2022
doi: 10.1007/s00223-022-0997-7
Uchida-Fukuhara Y, Hattori T, Fu S, Kondo S, Kuwahara M, Fukuhara D, Islam MM, Kataoka K, Ekuni D, Kubota S, Morita M, Ikegame M, Okamura H.
Maternal gut microbe decelerates fetal endochondral bone formation by inducing inflammatory reaction.
Microorganisms, 10(5):1000, 2022
doi: 10.3390/microorganisms10051000
Wang R, Luo H, Yang D, Yu B, Guo J, Shao L, Okamura H, Qiu L.
Osteoblast Jmjd3 regulates osteoclastogenesis via EphB4 and RANKL signaling.
Oral Diseases, 29(4), 1613-1621, 2022
doi: 10.1111/odi.14160.
Yu B, Wang R, Luo H, Yang D, Wang S, Yu Y, Okamura H, Qiu L.
Histone demethylase Jmjd3 regulates the osteogenic differentiation and cytokine expressions of periodontal ligament cells.
Acta Medica Okayama, 76(3), 281-290, 2022
doi: 10.18926/AMO/63722
Wang R, Luo H, Yang D, Yu B, Guo J, Shao L, Okamura H, Qiu L.
Osteoblast Jmjd3 regulates osteoclastogenesis via EphB4 and RANKL signaling.
Oral Diseases, 29(4), 1613-1621, 2022
doi: 10.1111/odi.14160.
2021年
Weng Y, Wang Z, Fukuhara Y, Tanai A, Ikegame M, Yamada D, Takarada T, Izawa T, Hayano S, Yoshida K, Kamioka H, Okamura H.O-GlcNAcylation drives calcium signaling toward osteoblast differentiation: A bioinformatics-oriented study.
BioFactors, 47(6), 992-1015, 2021
doi: 10.1002/biof.1774.
Yoshida K, Yoshida K, Fujiwara N, Seyama M, Ono K, Kawai H, Guo J, Wang Z, Weng Y, Yu Y, Uchida-Fukuhara Y, Ikegame M, Sasaki A, Nagatsuka H, Kamioka H, Okamura H, Ozaki K.
Extracellular vesicles of P. gingivalis-infected macrophages induce lung injury.
Biochimica Biophysica Acta-Molecular Basis of Disease, 1867(11), 166236, 2021
doi: 10.1016/j.bbadis.2021.166236.
17.Weng Y, Wang Z, Fukuhara Y, Tanai A, Ikegame M, Yamada D, Takarada T, Izawa T, Hayano S, Yoshida K, Kamioka H, Okamura H.O-GlcNAcylation drives calcium signaling toward osteoblast differentiation: A bioinformatics-oriented study.
BioFactors, 47(6), 992-1015, 2021
doi: 10.1002/biof.1774.
Reviews
Tanai A, Okamura H.
The role of extracellular vesicles throughout normal pregnancy and in relation to oral bacteria.
Journal of Oral Biosciences, 63(1), 14-22, 2021 Review
doi: 10.1016/j.job.2021.01.006.
Reviews
Okamura H, Hirota K, Yoshida K, Weng Y, He Y, Shiotsu N, Uchida-Fukuhara Y, Tanai A, Guo J.
Outer membrane vesicles of Porphyromonas gingivalis: novel communication tool and strategy.
Japanese Dental Science Review, 57, 138-146, 2021
doi: 10.1016/j.jdsr.2021.07.003.
Special Lectures
岡村裕彦
S-1 骨関連細胞における蛋白質脱リン酸化酵素と糖鎖修飾の役割
第29回硬組織再生生物学会学術大会，2021年8月28日，岡山大学（Zoom online）
2020年
Tran MT, Okusha Y, Feng Y, Morimatsu M, Wei P, Sogawa C, Eguchi T, Kadowaki T, Sakai E, Okamura H, Naruse K, Tsukuba T, Okamoto K.The inhibitory role of Rab11b in osteoclastogenesis through triggering lysosome-induced degradation of c-Fms and RANK surface receptors.
International Journal of Molecular Sciences, 21(24):9352, 2020
doi: 10.3390/ijms21249352.
Wang Z, Weng Y, Ishihara Y, Odagaki N, Ei Hsu Hlaing E, Izawa T, Okamura H, Kamioka H.
Loading history changes the morphology and compressive force-induced expression of receptor activator of nuclear factor kappa B ligand/osteoprotegerin in MLO-Y4 osteocytes.
Peer J, 8:e10244., 2020
doi: 10.7717/peerj.10244.
Guo J, Wang Z, Weng Y, Yuan H, Yoshida K, Ikegame M, Uchibe K, Kamioka H, Ochiai K, Okamura H, Qiu L.
N-(3-oxododecanoyl)-homoserine lactone regulates osteoblast apoptosis and differentiation by mediating intracellular calcium.
Cellular Signaling, 75, 109740, 2020
doi: 10.1016/j.cellsig.2020.109740.
He Y, Shiotsu N, Uchida-Fukuhara Y, Guo J, Weng Y, Ikegame M, Wang Z, Ono K, Kamioka H, Torii Y, Sasaki A, Yoshida K, Okamura H.
Outer membrane vesicles derived from porphylomonas gingivalis induced cell death with disruption of tight junctions in human lung epithelial cells.
Archives of Oral Biology, 118, 104841, 2020
doi: 10.1016/j.archoralbio.2020.104841.
Ono K, Sogawa C, Kawai H, Tran HK, Taha EA, Lu Y, Oo MW, Okusha Y, Okamura H, Ibaragi S, Takigawa M, Kozaki K, Nagatsuka H, Sasaki A, Okamoto K, Calderwood SK, Eguchi T.
Triple knockdown of CDC37, HSP90-alpha and HSP90-beta diminishes extracellular vesicles-driven malignancy events and macrophage M2 polarization in oral cancer.
Journal of Extracellular Vesicles, 9(1), 1769373, 2020
Okusha Y, Eguchi T, Tran MT, Sogawa C, Yoshida K, Itagaki M, Taha EA, Ono K, Aoyama E, Okamura H, Kozaki KI, Calderwood SK, Takigawa M, Okamoto K.
Cancers (Basel), 12(4), pii: E881, 2020
doi: 10.3390/cancers12040881.
Seyama M, Yoshida K, Yoshida K, Fujiwara N, Ono K, Eguchi T, Kawai H, Guo J, Weng Y, Haoze Y, Uchibe K, Ikegame M, Sasaki A, Nagatsuka H, Okamoto K, Okamura H, Ozaki K.
Biochimica Biophysica Acta-Molecular Basis of Disease, 1866(6), 165731, 2020
doi: 10.1016/j.bbadis.2020.165731.
Sumitani Y, Uchibe K, Yoshida K, Weng Y, Guo J, Yuan H, Ikegame M, Kamioka H, Okamura H.
Inhibitory effect of retinoic acid receptor agonists on in vitro chondrogenic differentiation.
Anatomical Science International, 95(2), 202-208, 2020
doi: 10.1007/s12565-019-00512-3.
Reviews
Guo J, Yoshida K, Ikegame M, Okamura H.
Quorum-sensing molecule N-(3-Oxododecanoyl)-L-Homoserine lactone: An all-rounder in mammalian cell modification.
Journal of Oral Biosciences, 62(1), 16-29, 2020 Review article
doi: 10.1016/j.job.2020.01.001.
2019年
Ikegame M, Ejiri S, Okamura H. Expression of Noncollagenous Bone Matrix Proteins in Osteoblasts Stimulated by Mechanical Stretching in the Cranial Suture of Neonatal Mice.
Journal of Histochemistry and Cytochemistry, 67(2), 107-116, 2019
Symposium
Hirohiko Okamura, Guo jiajie
Effect of bacterial quorum sensing factor on osteoblast differentiation and apoptosis
The 13th Japan-China joint seminar on histochemistry and cytochemistry (JCJSHC), Sep 19-21, 2019,
The Kobe Chamber of Commerce and Industry, Kobe-city
Symposium: New horizon of bone cell imaging
2018年
Eguchi T, Sogawa C, Okusha Y, Uchibe K, Iinuma R, Ono K, Nakano K, Murakami J, Itoh M, Arai K, Fujiwara T, Namba Y, Murata Y, Ohyama K, Shimomura M, Okamura H, Takigawa M, Nakatsura T, Kozaki KI, Okamoto K, Calderwood SK.Organoids with cancer stem cell-like properties secrete exosomes and HSP90 in a 3D nanoenvironment.
PLoS One, 13(2), e0191109, 2018
Yoshida K, Teramachi J, Uchibe K, Ikegame M, Qiu L, Yang D, Okamura H.
Reduction of Protein Phosphatase 2A Cα promotes in vivo bone formation and adipocyte differentiation.
Molecular and Cellular Endocrinology, 470, 251-258, 2018
Yang D, Okamura H, Qiu L.
Upregulated Osterix expression elicited by Runx 2 and Dlx5 is required for the accelerated osteoblast differentiation in PP2A Cα-knockdown cells.
Cell Biology International, 42(4), 403-410, 2018
Reviews
岡村裕彦
多彩な役割をもつ蛋白質脱リン酸化酵素PP2A
岡山歯学会雑誌, 36 (2), 25-36, 2018
2017年
Yoshida K, Okamura H, Hiroshima Y, Abe K, Kido JI, Shinohara Y, Ozaki K.PKR induces the expression of NLRP3 by regulating the NF-kB pathway in Porphyromonas gingivalis-infected osteoblasts.
Experimental Cell Research, 354(1), 57-64, 2017
Ma N, Yang D, Okamura H, Teramachi J, Hasegawa T, Qiu L, Haneji T.
Involvement of interleukin-23 induced by Porphyromonas endodontalis lipopolysaccharide in osteoclastogenesis.
Molecular Medicine Reports, 15 (2), 559-566, 2017
Teramachi J, Inagaki Y, Shinohara H, Okamura H, Yang D, Ochiai K, Baba R, Morimoto H, Nagata T, Haneji T.
PKR regulates LPS-induced osteoclast formation and bone destruction in vitro and in vivo.
Oral Disease, 23(2), 181-188, 2017
Reviews
Okamura H, Yoshida K, Morimoto H, Teramachi J, Ochiai K, Haneji T, Yamamoto A.
Role of protein phosphatase 2A in osteoblast differentiation.
Journal of Clinical Medicine, 6 (3):23, pii: E23, 2017 doi: 10.3390/jcm6030023, Review
Special Lectures
Hirohiko Okamura
Enjoy Research!
Special lecture in Chinese Medical University, 2017年9月25日，中国遼寧省 中国医科大学
Special Lectures
岡村裕彦
研究活動の楽しさと出会い
第38回岡山歯学会・学術集会，2017年10月1日，岡山大学歯学部棟4階